Abstract:Objective To investigate the expressions of IL8,MCP1 and MIP1α and their biological significance in pancreatic carcinoma and chronic pancreatitis, and investigate the relationships of their expressions in pancreatic cancer tissues.
Methods Immunohistochemical method of avidinbiotin complex was used to examine surgically removed specimens from 51 cases of pancreatic carcinoma and 10 cases of chronic pancreatitis.
Results The positive rates of expression and the scorings of IL8,MCP1,MIP1α were significantly higher in pancreatic carcinoma than that in chronic pancreatitis(P<0.01). IL8 expression was significantly higher in welldifferentiated adenocarcinoma than that in poorlydifferentiated ones(P<0.05). Also the positive expression rate and the scorings of the three factors were significantly lower in cases without metastasis than in those with metastasis(P<0.05 or P<0.01).
Conclusions The expressions of IL8,mcpI and MIPIα might be three important chemotactic factors in reflecting the carcinogenesis,progression,biological behavior,metastatic potential and prognosis of pancreatic carcinoma.The three factors might have mutual effect and common regulatory pathways of action.