Abstract:Objective：To study the effect of hyperbaric oxygen(HBO) treatment on plasma endotoxin, sCD14 and plasma endotoxin inactivation capacity(EIC) in acute necrotizing pancreatitis(ANP) in rats and its possible mechanism. Methods：SD rats were randomly divided into control group, sham operation group, ANP group and ANP+HBO group. Rat ANP models were made by retrograde injection of 3.5% sodium taurocholate(2.5mL/kg ) into the pancreatic duct. Thirty minues after models had been made, ANP+HBO group was treated by hyperbaric oxygen for 2h. At 3h, 6h, and 10h after establishment of rat models, the plasma endotoxin, sCD14, EIC, TXB2 and 6-K-PGF1a leves were determined in each group. Results：At 3h and 6 h after rat models were established, the levels of endotoxin, sCD14, and TXB2 in ANP+HBO group were significantly lower than those in ANP group （P< 0.05）;EIC level in ANP+HBO group was significantly higher than that in ANP group（P< 0.05）. Conclusions：Through improvement of microcirculation, HBO could increase the level of EIC and decrease the level of endotoxin and sCD14 in ANP rats.