Abstract:Objective：To investigate the protective effect of losartan on acute ischemia-reperfusion(I/R) injury of pancreas in rats. Methods：Seventy-two Wister rats were randomly divided into 3 groups:（1）Control group;（2）Ischemia-reperfusion group:the anterior mesenteric artery and the celiac artery were occluded for 15 min,30min and 60min followed by 6 hours reperfusion;（3）Losartan group:losartan（40mg／kg）were administered by gavage at 12h and 1h before arterial occlusion. The pathologic changes of pancreatic tissue were observed under light microscopy; TUNEL was used to detect apoptosic of pancreatic cells;Bcl-2 expression in the pancreatic cells of rats was analyzed by immunohistochemistry technique. Results：Losartan treatment reversed the histological abnormalities including infiltration of inflammatory cells and atrophy of acinar cells.Compared with losartan group,pancreatic tissue of I/R group exhibited increased MDA［（20.1±1.2）nmol/g and （34.9±2.6） vs（17.9±2.1）nmol/g and （25.2±3.3）nmol/g,P<0.05］ and apoptosis［（10.2±3.2）％ and （18.4±3.1）％ vs. （6.5±2.9）％ and （10.5±4.3）％,P<0.05］.The administration of losartan increased expression of Bcl-2（11.3±2.2）％ and （16.2±2.7）％ vs （6.1±1.7）％、（10.3±2.1）％，P<0.05）.Conclusions：Losartan can decrease the pathologic changes and suppress cell apoptosis in pancreas of rats with I/R.