Abstract:Objective：To study the therapeutic effects of combined use of laparoscopic cholecystetomy and endoscopic sphincterotomy for cholecystolithiasis with secondary choledocholithiasis. Methods：Thirty-five patients were diagnosed as cholecystolithiasis with secondary choledocholithiasis by B-ultrasonography and magnetic resonance cholangiopancreatography. Of them, in 28 cases, laparoscopic cholecystetomy was performed first, and ERCP and endoscopic sphincterotomy were done one week later; in 7 cases, endoscopic sphincterotomy were performed before laparoscopic cholecystectomy. Results：The outcome of all the thirty-five cases was satisfactory without severe complications or conversion into open procedure. Conclusions：The method of combined laparoscopic cholecystomy and endoscopic sphincterotomy, for cholecystolithiasis with secondy choledocholithiasis, especially for cases in whom the diameter of the common bile duct stone is ≤1cm, can give good therapeutic results and has advantages of minimal invasiveness, few complications and quick recovery.