Abstract:Objective：To study the BC047440 mRNA expression in human hepatocellular carcinoma tissues, and the role of BC047440 gene in the carcinogenesis and development of human hepatocellular carcinoma. Methods：Specimens from 36 cases of hepatocellular carcinoma and their corresponding adjacent non-cancerous tissues were examined for BC047440 mRNA expression by polymerase chain reaction after reverse transcription(RT-PCR). Results：（1）the BC047440 mRNA expression in specimens of 36 cases of hepatocellular carcinoma was higher than that in their adjacent non-cancerous tissues(0.2594±0.0928 and 0.0942±0.0443, respectively, P<0.01). （2）In BC047440 mRNA over expression group, the tumor was bigger, and invasion of portal was more severe than those in BC047440 mRNA high expression group(all P<0.05). Conclusions：The expression of BC047440 gene may be related to the cancinogenesis, the growth, infiltration and metastasis of human hepatocellular carcinoma.