Abstract:Objective：To summarize the clinical technique and experience of one stage combination of renopancreatic transplantation(SKPT) with portal venous drinage of pancreatic endocrine and enteric drainage of exocrine(PE). Methods：Five patients with insulin-dependent diabetes mellitus and end-stage renal disease underwent SKPT with PE drainage. The clinical data, operative techbuque, and the prevention of non-technical complications were summarized. Results：This procedure was successfully applied in the 5 patients. Three patients recovered excellently; but 2 died perioperatively, one died of sepsis due to pancreatic leakage, and one of FK506 toxicity. On postoperative day 3, in the 3 survivors, blood creatinine and urea nitrogen levels returned to normal; insulin administration was discontinued on 7d postoperatively, and the endogenous and exogenous secretory functions of the graft were normal.Conclusions：SKPT with PE is a resonable procedure, because of its potential physiologic,metabolic,and immunologic advantages. PE drainage may become the prefer technique of pancreas transplantation. Intensive perioperative managements are effective methods to prevent complications and to improve the therapeutic effects.