Abstract:Objective ：To elucidate the clinical features, and the principles in diagnosis and treatment of hyperlipidemic pancreatitis.Methods ：The clinical data of 262 cases with acute pancreatitis from January, 2004 to April, 2006, were studied. Results ：Among 262 cases, 46 cases were diagnosed as hyperlipidemic pancreatitis(17.5%,46/262), that included 32 cases with mild acute pancreatitis(69.0%) and 14 cases with severe acute pancreatitis(31.0%). Depending on the severity of pancreatitis, different treatments were adopted. Among the 46 cases, 10 were treated operatively. As a result, 43 cases were cured, accountingfor 93.5% of all cases, and3 cases died, accounting for 21.4% of cases with severe acute pancreatitis. Conclusions ：Hyperlipidemia can induce acute pancreatitis, and many may have severe pancreatitis. Treatment is mainly by nonoperative management but different therapeutic measures should be adopted according to the severity of pancreatitis.