Abstract:Objective ：To discuss the nonoperative management strategy to prevent the conversion of acute pancreatitis to the severe form. Methods ：In recent 4 years, 286 patients withmild acute pancreatitis admitted to our hospital were divided into control group and treatment observation group;routine conservative management was performed in control group, and the strategy of improving pancreatic microcirculation and preventing cell Ca 2+ overload and inhibiting pancreatic protease was added to the treatment observation group. Results ：Among the 144 patients with mild acute pancreatitis in control group, conversion to severe acute pancreatitis occurredin 20 patients, and 14 of the 20 patients with severe acute pancreatitis developed systemic complications. Among the 142 cases in treatment observation group, the conversion of mild to severe acute pancreatitis occurred in 8 patients, and 2 of the 8 patients developed systemic complications. Serum C-reactive protein levels and Balthazar CT severity index were significantly decreased at each time point in treatment observation group compared to control group. Conclusions ：In addition to routine management, improving pancreatic microcirculation, preventing cell Ca 2+ overload and inhibiting pancreatic protease might serve as a benificial strategy for preventing the progression of mild acute pancreatitis to the severe form.