Abstract:Objective：To study the application effect of fibrin sealant(FS) during operation for late-stage portal hypertension caused by schistosomiasis. Methods：From Jun,2003 to Jun,2005, 92 cases of late-stage portal hypertension caused by schistosomiasis treated by portal-systemic disconn-ection(PSD) operation were divided into two groups, namely PSD group and PSD+FS group. The early complications such as fever and exudate in splenic fossa, as well as long term complications such as recurrent bleeding, hypertensive gastropathy were compared in the 2 groups, and encephalopathy were compared between 64 cases of patients with FS and 28 cases of patients without FS. Results：The patients undergoing PSD+FS showed decreased the exudate in splenic fossa and fever(P<0.05, respectively). Recurrent bleeding rate was 1.6% in PSD+FS group and 14.3% in PSD group(P<0.05), and portal hypertensive gastropathy was 29.7% in PSD+FS group and 64.3% in PSD group(P<0.01), but the occurrence rate of hepatic encephalopathy was no different in the 2 groups(P>0 05). Conclusions：FS application during operation is effective in attenuating early and long term operative complications of portal hypertension caused by schistosomiasis, and improving outcome of surgical treatment.