Abstract:Objective:To investigate the relationship between peripapillary duodenal diverticulum and obstructive jaundice, and the diagnosis and treatment for this clinical entity. Methods:The clinical data of 25 cases of obstructive jaundice caused by peripapillary diverticulum were retrospectively reviewed. Results:All cases were diagnosed definitively by endoscopic retrograde cholangiopancreatography(ERCP). 20 cases underwent choledochostomy with T-tube drainage and subtotal gastrectomy (Billroth II) and recovered, and 5 cases were cured by nonoperative therapy and discharged asymptomatically, but followup showed they had recurrent attacks of symptoms. Conclusions:Obstructive jaundice caused by peripapillary diverticulum can be definitively diagnosed by ERCP, and should be treated by choledochostomy, T tube drainage and subtotal gastrectomy(Billroth II), which is a simple, rational, safe and effective surgical procedure.