Abstract:Objective To study the clinical effect of neoadjuvant chemotherapy(NAC) on advanced breast cancer.
Methods The CAF neoadjuvant chemotherapy ［CTX500mg/m2(1st day ，8th day)，5FUmg/m2(1st day，8th day)，and ADM 30mg/m2(1st day) every 3 weeks)］was carried out in 66 advanced breast cancer patients for 2 cycles before operation，and compared with 58 concurrent operable patients with advanced cancer, who did not receive any preoperative therapy.
Results The overall response rate was 86.36%(57/66) in NAC group. The stages of 41 of the 66 patients(62.12%) was downgraded.The disease free survival time of the patients was 57.6 months which was obviously longer than that of patients without neoadjuvant chemotherapy (42.20 months，p<0.05).〖JP2〗The 5year diseasefree survival rate of the patients with neoadjuvant chemotherapy was 37.89% which was a little higher than that(34.48%)of the patients without the chemotherapy, but the two groups had no significant difference.
Conclusions Neoadjuvant chemotherapy can downgrade the stage of patients with advanced breast cancer，provide an optimal time for operation, obviously prolong the diseasefree survival time of the patients，and reduce or delay recurrence or metastasis.