Abstract:Objective To investigate the clinical characteristics, diagnosis and treatment of patients with carcinomatous change of breast intraductal papillomas(IP).
Methods The clinical and pathologic data of 22 patients treated from Jan 2000 to Jan 2005 were analyzed restrospectively.
Results The 22 patients accounted for 4.61%(22/477) of patients with IP and 5.96%(22/369) of patients with breast cancer during the same period. Tweenty of the 22 patients did not have biopsy, and a definite diagnosis was not made before operation. Frozen section established the diagnosis in 13 of the 20 cases, but was negative in 7 cases. In this series, 2 cases received segmental mastectomy, 16 cases received total mastectomy, and 4 cases received modified radical mastectomy (the postoperative pathology confirmed that no axillary node metastasis was found).
Conclusions It is difficult to diagnose the carcinomatous change of breast intraductal papillomas before operation, because there are no spelific clinical characteristics, and frozen section is considerable to confirm the diagnosis, and the treatment of choice is simple mastectomy.