Abstract:Objective To investigate the role of βcatenin gene in breast tumorigenesis.
Methods Mutation and expression of βcatenin gene in 42 breast cancer tissues were detected by polymerase chain reactionsingle strand conformation polymorphism and immunohistochemistry.
Results The rate of abnormal expression of βcatenin in breast cancer tissuse was 59.5%（25／42）. Mutation of βcatenin gene was not detected in breast cancer tissue.
Conclusions Abnormal expression of βcatenin plays an important role in human breast tumorigenesis, but the cause of abnormal expression of βcatenin is not mutation of βcatenin gene.