Abstract:Objective
To investigate the expression level of RECK mRNA and MMP9mRNA in breast cancer(BC) and fibroadenoma tissues and its significance.
Methods The mRNA level of tissues of 39 cases of breast cancer and 14 cases of fibroadenoma was measured by RTPCR technique and its correlation was analyzed.
Results The mRNA level of RECK gene in breast cancer tissues was markedly lower than that in fibroadenoma tissues, while the MMP9 level was higher in BC tissues.
Conclusions RECK is a tumor suppressor gene, the expression in benign and malignant breast tissues is a negative relationship. BECK can inhibit the expression of MMP9 and thus, inhibit the growth and metastasis of breast cancer.