Abstract:Objective：To investigate the expression of focal adhesion kinase in peripheral blood of colorectal cancer and its clinical significance.
Methods ：Focal adhesion kinase in peripheral blood was determined with flow cytometry in 40 cases of colorectal cancer and 20 cases of control group.
Results：The positive rate of focal adhesion kinase in colorectal cancer group was 60.0% and in control group was 25.0% ,respectively(P<0.05). Mean value of focal adhesion kinase expression was high in cases with cancers and was related to clinical stage, degree of histological differentiation, and lymphatic metastasis.
Conclusions：Focal adhesion kinase expression in human peripheral blood lymphocytes may be related with the tumor load statue, and can be used as an index for surveillance and screening of colorectal cancer high risk population.