Abstract:Objective：To investigate the therapeutic effects and mechanism of dbcAMP-Ca in treatment of rats with gastric stress ulcers induced by internal capsule hemorrhage.
Methods ： The levels of pituitary adenylate cyclase activiting poly-peptide (PACAP) in plasma and stomach tissues of rats with cerebral hemorrhage and treated by dbcAMP-Ca after 24h were determined by RIA.
Results：The level of PACAP in plasma of cerebral hemorrhage group was significantly higher than that in control group(P＜0.01), and the level of PACAP in stomach tissues of cerebral hemorrhage group was lower than that in control group(P＜0.01). The level of PACAP in plasma of treatment group was significantly lower than that in cerebral hemorrhage group(P＜0.01).and the level of PACAP in stomach tissues of treatment group was higher than that in cerebral hemorrhage group (P＜0.01).
Conclusions：PACAP may play some important role in gastric stress ulcers induced by internal capsule hemorrhage, and dbcAMP-Ca has an important effect in treatment of rats with gastric stress ulcers induced by internal capsule hemorrhage.