Abstract:Objective:To investigate the effect of ulinastatin on Oddi sphincter after pancreatic transplantation in the dog.
Methods :Ten thousand and thirty thousand units ulinastatin were injected into normal dogs and dogs undergoing pancreatic transplantation, and then the pressure of Oddi sphincter was measured.
Results:In normal dogs, there was no significant difference between basic pressure and contraction pressure (P>0.05),but the contraction frequency and kinetic index were both decreased(P<0.01). The kinetic index when injecting ten thousand units ulinastatin was stastically different to that when injecting thirty thousand units ulinastatin(P<0.01),but there was no difference in contraction frequency(P>0.05). In pancreas transplantation dogs, the basic pressure,contraction frequency and kinetic index were all decreased with usage of ulinastatin(P<0.01) and there was a difference between the ulinastatin dosage of ten thousand units and that of thirty thousand units (P<0.05).
Conclusions:Ulinastatin could restrain the movement of Oddi sphincter,and this effect had a positive correlation with dosage,especially after pancreatic transplantation. Ulinastatin can effectively reduce basal sphincter pressure, improve the drainage of pancreatic fluid and is conducive to prevention and treatment of pancreatitis after transplantation.