Abstract:Objective:To study the clinicopathological features of chronic inflammatory mass lesion of the pancreas.
Methods : The clinical data of 37 patients with focal chronic inflammatory mass lesion of the pancreas were retrospectively studied. Seventeen cases congruent with the standard clinical diagnostic of chronic pancreatitis were separated into group A; and Whipple procedure was carried out in two cases, resection of the body and tail of the pancreas in 2 cases, local resection in one case, and choledochojejunostomy in 12 cases. Those without the stander clnical features of Group A but with the features of pancreatic tumor were separated into Group B; and Whipple procedure was carried out in 4 cases, choledochojejunostomy in 16 cases.
Results: In group A, except for the local mass lesion, sclerosis of the whole pancreas was found in 88.2% of cases. Pathological examination showed proliferation of fibrous tissue with associated inflammation, as well as acinar atrophy, remnant islet cells, and ductular dilatation and focal calcification. While in Group B, only a local mass lesion of the pancreas was found in 19 cases. The pathological features were characterized histologically by proliferation of fibrous tissue with associated moderate or marked inflammation. No pancreatic carcinoma was found during 1 to 12 years follow-up of 33 cases.
Conclusions:Chronic inflammatory mass lesion of the pancreas showed the clinicopathological features of pseudotumoral pancreatitis. Internal drainage by choledochojejunostomy is suggested as its effective management.