Abstract:Objective:To summarise the perioperative features of orthotopic liver transplantations(OLTs) in miniature porcine, to establish mature、stable OLT models.
Methods:In order to observe hemodynamics and blood changes and improved perioperative management and summarise the perioperative characteristics, 8 preliminary experiments (group A) and 18 experiments (group B) of OLTs were performed without veno-venous bypass(VVB) in Chinese inbred miniature porcine.
Results:The mean operation time was （179.6±14.3）min in our 18 OLTs, and the mean anhepatic phase time was（27.3±3.4）min. Dramatic hemodynamic and metabolic changes were identified during anhepatic phase. The one- week survival rate was 88.9% in group B, but all the 8 pigs in group A died. The experiment group pigs urinated after 3～5hours and had normal diet after 3days.
Conclusions:Decreasing the operation time and stability of hemodynamics in anhepatic phase are the keys for success in OLTs without VVB.