Abstract:Objective To investigate the diagnosis of primary duodenal carcinoma and its outcome after surgical treatment.
〖WTHZ〗Methods The clinical data of 85 patients with primary duodenal carcinoma treated operatively between 1997 and 2006 were analyzed retrospectively.
Results The correct diagnosis rate for endoscopy was 86.8%(66/ 76),for duodenography 84.3% (16/ 19),for ultrasound examination 28.2% (24/85) and for computerized tomography (CT) scanning 39.6% (21/53), respectively.All of the 85 patients received surgery including pancreaticoduodenectomy (PD) in 61 patients, duodenal segmental resection (SR) in 8, subtotal gastrectomy in 2 and bypass operation in 14.The 1,3, and 5 year survival rate of all patients was 84.4%，58.3%, and 31.9% respectively.The 1,3, and 5 year survival rates of patients receiving PD and SR were 100.0%，67.7%，41.6% and 100.0%, 60.0%, 0.0%,respectively. With univariate analysis, radical resection(PD and SR), infiltration and lymph node metastases were found to be significant factors associated with overall postoperative survival. With multivariate analysis, radical resection, lymph node metastases and depth of local tumor infiltration independently affected the overall postoperative survival.
Conclusions Duodenography and endoscopy can increase the rate of early diagnosis of primary duodenal carcinoma. Radical resection can improve the longterm survival of patients with primary duodenal carcinoma.