Abstract:Objective:To investigate the diagnosis and treatment method of fungal infection after orthotopic liver transplantation(OLT).
Methods:A retrospective survey of 29 fungal infection patients in 147 patients who underwent liver transplantation was made.
Results:Twentynine patients(19.73%) had 48 occurrences of invasive fungal infection.Lung fungal infection was found in 16 cases(33.34%),intestine in 11 cases(22.92%), and genitourinary system in 10 cases(20.83%). Pathogens were Candida albicans (52.08%), Candida tropicalis (12.50%), Aspergillus(8.34%) and mold fungus(4.17%).Twelve cases were effectively treated with fluconazole, 8 cases with itraconazole, and 4 cases with caspofungin. 24 cases were cured with the curative rate being 82.76%,and 5 cases died with the mortality being 17.24%.
Conclusions:The rate of fungal infection after liver transplantation is high. Imaging and pathogenic studies should be done to early diagnose fungal infection, which could be timely treated with effective antifungal agents，such as fluconazole, itraconazole and caspofungin.