Abstract:Objective:To study the relationship between the molecular biology and the clinicopathologic characters with prognosis of colorectal cancer.
Methods :The molecular biology traits and clinical characters and prognosis of 317 colorectal cancer patients were compared by mono-factorial analysis; some of them regarded as statistical difference by mono-factorial analysis were analyzed with Cox model.
Results:There was statistical difference for the p53,C-erb-2,nm23,CEA,cell differentiation and Dukes stages with Kaplan-meier′s method (P>0.05). p53,C-erb-2,nm23 and Dukes stages with Cox model (P>0.05). The prognosis was worse with increase in Dukes stage, negative expression of gene nm23, and positive expression of gene p53 and C-erb-2. Reverse expressions had better prognosis.
Conclusions:It can be likely to get a more reliable prognosis predication if a combine examination together with p53, C-erb-2, nm23 and their clinical pathology such as Dukes stages, was done in colorectal cancer patients.