Abstract:Objective:To investigate the strategy and outcome of prevention of hepatitis B virus(HBV) reinfection after orthotopic liver transplantation (OLT).
Methods :A total of 120 patients with chronic fulminant hepatitis B，end-stage of liver cirrhosis and liver carcinoma were given hepatitis B immunoglobulin (HBIG) plus lamivudine or adefovir after OLT to prevent HBV reinfection．The serum HBV and HBV DNA were determined and clinical observation were performed.
Results:Follow-up time ranged from 23-59 (median 45.2) months. Four patients had reinfection with positivity of HBsAg，HBeAb and HBcAb, the serum HBV DNA was also positive．All 4 patients became HBV-DNA negative after treatment and folloed-up for 19-26 months, but HBsAg remained positive.
Conclusions:HBIG plus lamivudine or adefovir can effectively prevent HBV reinfection after OLT. Load level of HBV-DNA before OLT was related with HBV reinfection after operation.