Abstract:Objective:To explore the effects of Gln-glutamine (Gln-) supplemented TPN and traditional TPN on immunofunction, incidence of both rate of acute rejection and infection, and protein synthesis function of transplantation liver.
Methods :Fifty patients with liver transplantation were randomly divided into two groups: group TPN without Gln- and group TPN with Gln-. Patients received isocaloric ［104.6 kJ /(kg·d)］ and isonitrogenous ［(0.16g/(kg·d)］ TPN for seven days. IgG，IgA，IgM, CD3,CD4/CD8, prealbumin(PAB) were monitored on the second and the ninth day after transplantation.
Results:IgG, IgA, CD3, CD4 /CD8,PA levels of the group TPN with Gln- had significant elevation on the ninth day as compared to those on the second day after operation. The incidence rate of infection of the group TPN with Gln- was significantly lower than the group TPN without Gln-, while the incidence rate of acute rejection had no significant difference between the two groups.
Conclusions:Gln-glutamine supplemented TPN can enhance the immunofunction of patients after liver transplantation, stimulate protein synthesis function and lower the incidence rate of infection, and does not increase the incidence of acute rejection.