Abstract:Objective:To observe the manifestations and judgement methods of acute rejection reaction of orthotopic liver transplantation in Wistar-SD rats.
Methods :The survival conditions after operation in rats was observed, and liver function tests and histopathology examination were used to study the manifestations of acute rejection reaction of orthotopic liver transplantation in Wistar-SD rats.
Results:Wistar-SD experiment group had moderate to severe acute rejection reaction after OLT. Alanine aminotransferase, aspartate aminotransferase, total bilirubin in blood serum after orthotopic liver transplantation in rats was obviously elevated on 1-3 d and 7 d after OLT, which are significantly different from every corresponding time point of control group(P<0.05).
Conclusions:Liver transplantation from donor Wistar rats to recipient SD rats can result in moderate to severe acute rejection reaction, and changes in results of liver functional parameters can indicate whether the acute rejection reaction has occurred.