Abstract:Objective:To analyze the expression of HLJ1 in the tissues of hepatocellular carcinoma(HCC) and the correlation between its expression and clinical pathological characteristic.
Methods :HLJ1 mRNA expression level was determined in 32 HCC tissues and their associated noncancerous liver tissues by reverse transcription polymerase chain reaction (RT-PCR). The correlation of HLJ1 expression level with clinicopathologic variables was also analyzed.
Results:HLJ1 mRNA expression level was significantly lower in HCC than in associated noncancerous liver tissue ［(1.18±0.82) vs. (1.92±1.15), P＜0.05］. Importantly, the HLJ1 mRNA expression level correlated with the Edmondson-Steiner grade (P=0.010) and vein invasion (P=0.001).
Conclusions:Our study indicates that HLJ1 mRNA expression level is significantly lower in HCC tissues than in associated noncancerous liver tissue. HLJ1 may participate in the cell proliferation and invasiveness of HCC cell.