Abstract:Objective:To explore the variations of regeneration hormones after hepatectomy for liver cancer, and evaluate the relationship between the liver regeneration hormones and cancer recurrence.
Methods :The clinical data of 129 patients with primary hepatic carcinoma in our hospital from Dec 2004 to Dec 2005 were collected. The patients were divided into three groups according to their recurrent times, which were one-month recurrence group, 6 months recurrence group and one-year recurrence group. And at the same time, 40 cases of liver cancer that received TAE treatment were as contrast group. Serum HGF value was detected before operation and 1, 3, 7,10 and 14 days after operation. c-met, which is the receptor of HGF, was also detected as c-met mRNA and protein expression in cancer tissue and near-carcinoma liver tissue by semi-quantitative RT-PCR and Western Blot. The differences between the level of expression and the time of recurrence were compared, and the results were also compared with pathological indexes.
Results:Serum HGF value elevated after hepatectomy, the crest time appeared at about 10 days after the operation, and decreased after 14 days. The elevated values of HGF in large HCC tumors were markedly higher than those in small HCC tumors. The change of c-met mRNA and protein levels, revealed that the earlier the recurrence in both large and small HCC, the higher the c-met levels, and the higher the rate of vascular cancer emboli.
Conclusions:There is marked elevation of HGF level after hepatectomy in patients with liver carcinoma, and the over expression of c-met of the tumor may be related to its early postoperative recurrence.