Abstract:Objective: To study the clinical characteristics and essential points of diagnosis and treatment of hepatolithiasis associated with cholangiocarcinoma.
Methods :The clinical data of 55 cases of hepatolithiasis associated with cholangiocarcinoia were analyzed retrospecively. Among them, radical resection was performed in 23 cases and palliative resetion in 32 cases.〖JP3〗
Results:The pathological diagnosis was biliary adeniocarcinoma〖JP〗 in 41 cases, and mucinous carcinoma in 14 cases. Fifty-one patients were followed up for an average 3 years and 9 months, the radical treated group survived an average of 26 (13-45) months, and the palliative conservative treatment group survived an average of 10 (5-14) months. The 1,2,3-year survival rates of radical treatment group was 96.4%, 54.6%, and 24.5% respectively, and for palliative treatment group, the 1-year survival rate of 37.8%, and none survived for 2 years.
Conclusions:Hepatobiliary gallstones can repeatedly develop inflammation that can lead to cholangiocarcinoma. Radical resection can prolong survival time, while palliative surgical treatment can improve quality of life. The key to improve the therapeutic outcome of hepatolithcasis with cholangiocarcinoma is to strive for early complete treatment of hepatobiliary gallstone.