Background and Aims Gallbladder carcinoma (GBC) is the most common malignant tumor of the biliary system, accounting for 80%-95% of biliary malignancies worldwide, and has a poor prognosis with a 5-year overall survival (OS) rate of only 10%-25%. At present, radical resection is the only possible way to cure GBC, but the recommended scopes of hepatic resection for T2 GBC are different in different guidelines. Therefore, this study was conducted to systematically evaluate the optimal scope of hepatectomy for T2 GBC.Methods Computer retrieval was performed in PubMed, Embase, Web of science, Cochrane Library, China Biology Medicine disc (CBMdisc), China National Knowledge Infrastructure (CNKI), Wanfang Database and VIP Database according to the inclusion and exclusion criteria, and the quality of eligible literature was assessed by the Newcastle-Ottawa Scale. RevMan version 5.4 software was used to analysis the difference of 1-, 3-, 5-year OS rate of patients of each group.Results Finally, 8 papers were selected, all included stage T2 GBC, and two of which included stage T2a and T2b GBC. Meta-analysis results showed that there was no difference in R₀ and R₁ section of stage T2 GBC between the wedge liver resection with at least a 2-cm margin from the gallbladder bed and liver segment Ⅳb+V resection in 1-, 3-, and 5-year OS rate (OR=0.70, 95% CI=0.45-1.09, P=0.12; OR=1.10, 95% CI=0.79-1.53, P=0.58; OR=1.18, 95% CI=0.89-1.56, P=0.25). There was no significant difference in 1- and 5-year OS rates for R₀ resection (OR=0.84, 95% CI=0.49-1.44, P=0.53; OR=0.89, 95% CI=0.64-1.25, P=0.51), while the 3-year OS rate was significantly different (OR=1.46, 95% CI=1.03-2.07, P=0.03). There was no significant difference in the 5-year OS rate of R₀ section of stage T2a and stage T2b GBC with liver tissue resection with at least a 2-cm margin from the gallbladder bed and the liver segment Ⅳb+V resection (OR=0.55, 95% CI = 0.18-1.64, P=0.28; OR=0.99, 95% CI =0.49-2.00, P=0.97).Conclusions Both liver tissue resection with at least a 2-cm margin from the gallbladder bed and the liver segment Ⅳb+V resection can be performed to achieve R₀ resection for stage T2 GBC.