Advances in research of animal models of alcoholic acute pancreatitis
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1.Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;2.Department of Gastroenterology 3. The Third Department of Neurology, Gansu Provincial Hospital of TCM, Lanzhou 730050, China

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R657.5

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    Abstract:

    Alcoholic acute pancreatitis (AAP) is currently the second most severe type of acute pancreatitis (AP) following acute biliary pancreatitis (ABP), with a more serious illness, higher mortality rate, and more severe multiple organ damage. Studies have shown that alcohol increases the risk of development of severe acute pancreatitis (SAP), and AAP is more likely to develop into SAP than ABP. In recent years, AAP-related research has become a hot topic, and obtaining ideal animal models can help in-depth research on the pathogenesis of AAP. However, there is a lack of effective methods for AAP animal model construction at present. Therefore, the authors review the common methods for AAP animal models at home and abroad, so as to provide new ideas for AAP research.

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LI Meina, LI Shengcai, CHANG Tiaofang, HU Zongxuan, ZHANG Xutong. Advances in research of animal models of alcoholic acute pancreatitis[J]. Chin J Gen Surg,2023,32(3):448-453.
DOI:10.7659/j. issn.1005-6947.2023.03.015

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History
  • Received:April 26,2022
  • Revised:August 31,2022
  • Adopted:
  • Online: March 30,2023
  • Published: