Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignant tumor arising from the epithelial cells of the second-order or more proximal bile ducts. ICC usually has no early warning signs, so most patients are diagnosed at an advanced stage and have no chance of radical surgery. With the introduction and widespread implementation of multidisciplinary diagnosis and treatment model for ICC, the disease control effect and survival time of patients have been improved, but the prognosis is still unfavorable. In the current surgery-based multidisciplinary diagnosis and treatment approach, attention should be focused on the mid- and long-term benefits to patients, and take this as the end goal throughout the whole process of treatment. Given the diversity of treatment options and the complexity of the disease, all treatment strategies recommend creating individualized management plans based on multidisciplinary discussion, and that the diagnosis and treatment should be conducted at or directed by a highly specialized hepatobiliary and pancreatic center. Here, the authors emphatically describe the development status and strategies of multidisciplinary diagnosis and treatment of ICC.