Background and Aims Short bowel syndrome is a rare disease caused by extensive small bowel resection, which has gradually attracted the attention of scholars in recent years. However, there is currently no related bibliometric study on this disease. Therefore, this study was conducted to describe the hotspots and trends in short bowel syndrome research over the past 30 years through bibliometric analysis.Methods Publications related to short bowel syndrome between 1991 and 2021 were searched in the Web of Science core database and imported into VOSviewer and CiteSpace software in plain text format. The data were processed using bibliometric methods to perform literature visualization analysis of authors, countries, institutions, highly cited literature, co-citation analysis, keywords, and references.Results A total of 3 439 articles were retrieved, involving 12 457 authors, 2 557 organizations, 74 countries/regions, and 779 journals. The literature cited a total of 64 834 articles authored by 43 194 individuals from 8 713 journals. Among them, the United States made the most significant contribution, and Wales PW was the most productive author. The University of Toronto was the most prolific institution, and the Journal of Pediatric Surgery was the core journal in this field. Keyword analysis showed that Short Bowel Syndrome, Intestinal Failure, Children, and Parenteral Nutrition were high-frequency keywords. Currently, research focuses on the classification, treatment, and management of this disease.Conclusion Over the past 30 years, the number of publications on short bowel syndrome has gradually increased, and the United States is at the forefront of research in this field. In addition, the classification, treatment, and management of short bowel syndrome have become potential hotspots.