Neutrophil extracellular traps (NETs) are special networks composed of DNA chromatin and various granular proteins that neutrophils release extracellularly in response to stimuli such as viruses, bacteria, immune complexes, and cytokines. As an important component of the innate immune extracellular defense system, NETs play a crucial role. Under normal circumstances, NETs mediate antimicrobial activity and pathogen clearance, thereby maintaining the body's protection against external threats. However, excessive or dysfunctional NETs can further amplify inflammatory responses and contribute to the occurrence and development of various diseases. The formation of NETs is closely associated with autoimmune diseases, diabetes, cardiovascular diseases, cancer, and more. In this review, the authors provide an overview of the role of NETs formation in regulating the occurrence and development of colorectal cancer (CRC). The review discusses the mechanisms by which NETs formation promotes malignant biological behaviors in CRC, including proliferation, epithelial-mesenchymal transition, angiogenesis, immune evasion, and tumor-related thrombosis. Furthermore, the review discusses the clinical prospects of NETs formation as a biomarker and potential therapeutic target for CRC.