Background and Aims Insulinoma is the most common functional neuroendocrine tumor of the pancreas. However, there have been few bibliometric studies on insulinoma. Therefore, this study was conducted to describe the hotspots and trends in insulinoma research over the past 20 years through bibliometric analysis.Methods Publications related to insulinoma between 1999 and 2021 were searched in the Web of Science Core Collection (WoSCC), and the results were imported in plain text format into VOSviewer and CiteSpace software for bibliometric analysis. The data was processed using bibliometric methods to conduct visual analysis of authors, countries, institutions, highly cited works, co-citations, keywords, and references.Results A total of 3 863 publications were retrieved, including 19 310 authors, 3 268 organizations, 83 countries/regions, and 1 005 journals. The literature cited a total of 85 078 articles authored by 55 619 individuals from 7 494 journals. Among them, research on insulinoma was mainly conducted in the United States, with Lernmark A being the most prolific author and the University of Washington being the most significant contributor. The Journal of Biological Chemistry was the main journal for publishing research in the insulinoma field. Keyword analysis showed that the current focus is mainly on "Pancreatic Neuroendocrine Tumor" "ENTS Consensus Guideline" "Marker" "Management" and "Neoplasm" indicating that the focus of insulinoma research has gradually shifted from a simple overview, diagnosis, clinical manifestations, and complications of this disease to the exploration of neuroendocrine tumors as a whole.Conclusions In the past 20 years, the publication output of insulinoma has remained at a highly explosive level. The United States has an unshakable position in this field. In addition, the efficacy of emerging tumor markers and how to develop more rational management modes are likely to become future research hotspots. Our study will help predict the development and trends in the field of insulinoma.