Contrast-enhanced ultrasound (CEUS) is a relatively simple, repeatable, real-time dynamic, and safe ultrasound examination technique that provides a highly sensitive reflection of the microcirculatory perfusion in lesions. It has become one of the fastest-growing technologies in the field of ultrasound medicine. Here, the authors provide an overview of the recent applications and research progress of CEUS in pancreatic cystic/solid lesions, so as to gain a more comprehensive understanding of the diagnostic and therapeutic advantages of CEUS in the qualitative analysis of pancreatic cystic/solid lesions as well as the challenges it faces, and thereby enhance its clinical utility.