Objective:To evaluate the effect of varicose vein of lower limbs treated by intravenous laser treatment.Method:Intravenous laser apparatus combination with operation was used to treat the varicose vein of the lower extremities in 98 patients(all 118 legs).The change of symptoms and signs were recorded and compared before and after operation by using venous ultrasonagraphy and pathological examination to evaluate the treatment effect.Results:In the 84 followed up patieats (104 compromised legs),dull,heaviness were relieved completely after operation in 87 legs(83.7%),decreased in 11 legs(10.6%);skin pigmentation obviously decreased in 37 of 44 legs(84.1%);superficial varicose vein disappeared in all the patients.No blood flow signal was detected in 101 legs(97.1%) and slow blood flow in 3 legs(2.9%) were detected by ultrasounography.Pathological examination revealed various degeneration and necrosis in full layers of the vessels;and smooth muscle cells were disrupted,cell nucleus became pyknotic, the internal and external elastic laminar were ruptured and no inflammatory cell infiltration in the lumen and wall of the vessels were seen.Conclusions:Intravenous laser treatment is an ideal method in the treatment of varicose vein of lower extremities.