Objective:
To explore the therapeutic effect of dual perfusion embolization and chemotherapy via hepatic artery and portal vein(combmation treatment) in the treatment of unresectable PHC.Methods : Eightyone cases of unresectable PHC were randomly divided into two gronps: (1) Combination treatment group.Fortyone cases,These cases received embolization and chemotherapy via hepatic artery and portal vein through a drug delivery system intraoperatively,and then embolization and chemotherapy via the drug pump were given periodically. (2) TACE group.Forty cases.These cases were treated with Seldinger's technique, the dosage of drugs were the same as used in the former group during laparotomy. After 3 times of treatment, AFP, the size of tumor, liver function, body weight, abdominal perimeter, survival time of the two groups were compared.Results : The weight, AFP, decrease of tumour size in combination group were much better than those in TACE group(P<0.01); but liver function, abdominal perimeter of the two groups were no significant difference(P>0.05). The median survival time in the two groups were 18.0 months and 11.1 months (P=0.0001). The accumulating survival rate of 6, 9, 12, 24 months were 87.8%,78.0%, 68.2%,31.7% in combination group, and 70.0%, 52.5%, 30.0%, 5.0% in TACE group, respectively. The factors affecting survival were therapeutic method, liver function, size of tumour.