Abstract:Objective:To investigate the renal hemodynamic changes after orthotopic liver transplantation(OLT)and the correlative parameters. Methods: In 20 patients undergoing OLT for cirrhosis,the following renal arterial resistance index(RI) was measured before surgery and 7days,30days, 6 months and 1 year after operation by using color Doppler flow imaging(CDFI) and serum creatinine detection.Meanwhile the same parameters were measured in 10 healthy as controls. Results: Both RI and serum Cr rised after OLT (P<0.01), restored to normal after OLT in 1 year(P>0.05). Conclusions:Most alteration of renal hemodynamic parameters in cirrhosis are restored to normal after OLT in 1 year. Preoperative renal abnormalities and intraopterative alteration of hemodynamic may contribute to postoperative renal dysfunction.Cyclosporine(CsA) is the most likely etiologic agent of postoperative renal dysfunction.