ObjectiveTo evaluate the dangerous and experience of cholecystectomy in patients with liver cirrhosis. MethodsThe clinical data of 40 patients with liver cirrhosis undergoing cholecystectomy were retrospectively analyzed. ResultsCholecystectomy was successfully performed in 38 patients. Intraoperative rupture of gallbladder bed with severe hemorrhage occurred in 4 cases, and extensive oozing of blood from gallbladder bed in 11 cases. In those 15 cases, the gallbladder bed was packed with omental pedicle, the bleeding was successfully controlled in all of the 15 cases, and with no rebleeding postoperatively. Intraoperative blood loss avcraged 400ml, but 1 case had the maximum blood loss which was>10 000ml. Six cases developed ascites postoperatively. There was no mortality or bile duct injury. The average hospital stay was 15d.ConclusionsIntraoperative bleeding and bile duct injuries are the major dangers of cholecystectomy in patients with liver cirrhosis, and packing of gallbladder bed with pedicle of greater omentum is a satisfactory method of hemostasis.