ObjectiveTo explore the effect and clinical significance of expression of nuclear factorκB(NFκB), ICAM1 and COX2 on the occurrence and metastasis of gastric carcinoma. MethodsThe expressionof NFκB, ICAM1 and COX2 in 142 patients with gastric carcinoma was examined by immunohistochemicalSP technique. The adjacent gastric tissue(30 cases) served as a control group. ResultsThe expression of NFκB was 62.0% in gastric carcinoma tissue, much higher than that of the control group (P<0.01).The positive rate of NFκB was significantly related to local lymph node metastasis, histological differentiation grade and distant metastasis (P<0.05). The expressions of ICAM1(72.5%) and COX2(64.1%) in gastric carcinoma were higher than those in the control group (P<0.01) and were both closely related to local lymph node metastasis (P<0.01). NFκB expression positively correlatedwith ICAM1 (rs＝0.477，P<0.01) and COX2(rs＝0.380，P<0.01). ConclusionsThe control of transcription of ICAM1 and COX2, NFκB plays an important action in the occurrence and metastasis of gastric carcinoma. It could become a new target of treatment of gastric carcinoma.