Objective;To investigate the expression of 5LOX in pancreatic cancer tissue and the relationship between 5LOX expression and expression of VEGF.Methods;The expression of 5LOXmRNA, VEGFmRNAin 35 pancreatic cancer fresh tissue samples were detected by semiquantitive reverse transcriptasepolymerase chain reaction method.Results;Expression of 5LOXmRNA，VEGFmRNA in pancreaticcancer tissue were 74.3%, 60% respectively,and the expression was correlated to the with clinicalstages of the tumor; also expression of VEGFmRNA was correlated to the differentiation of the tumor. Expression of 5LOXmRNA and VEGFmRNA were synergetic in pancreatic cancer(P<0.05), and were closely correlated(P<0.01). III~IV stages of pancreatic cancer showed significantly stronger expressions of 5LOX compared to in I~II stages of pancreatic cancer（P<0.05）. Conclusions;Expression of 5LOX，VEGF in pancreatic cancer tissue was markedly elevated,and correlated to the clinical stages of the tumor; expression of 5LOX and VEGF were positively related in pancreatic cancer.