Objective;To study the clinical significance of changes of plasma GMP140 and lipid levels in patients with acute pancreatitis. Methods;GMP140 was determined by ELISA and plasm a lipid levels were determined with an autobiochemical analyzer in 58 patients with acute pancreatitis and in 33 healthy individualsas control group. Results;The levels of plasma GMP140 , total cholesterol (TC), lowdensity lipoprotein (LDLC) in acute pancreatitis were higher than in the that control group(P<0.01)；and the levels of plasma GMP140 , TC, LDLC in severe acute pancreatitis(SAP) were significantly higher than that in mild acute pancreatitis(MAP) and control group( P<0.01)；There was a positive correlation betweenGMP140 and TC, LDLC（γ=0.7189 and 0.6121）. Conclusions;SAP patients had a high level of platelet activation. The levels of TC and LDLC were elevated in all of the patients with SAP or MAP. Platelet activation is closely correlated with higher cholesterol level.