Objective;To analyse the causes of postoperative complications of pancreatoduodenectomy (PD) and study measures for prevention and treatment of the complications.Methods;A retrospective study was carried out on the data of 139 cases of pancreatoduodenectomy performed during recent 3 years in our hospital. They included 91 cases of radical resection operation and 43 cases of pancreatoduodenectomy combinedwith vascular resection.Results;There were 38 cases (27.4%) occurred complications after PD,including 10 cases (7.2%) of upper gastrointestinal hemorrhage,4 cases (2.9%) of hemorrhage in the abdominal cavity,and 6(4.3%) cases of pancreatic leakage,4cases (2.9%) of bile duct leakage,3(2.2%) cases of intraabdominal infection,5 cases (3.6%) of pulmonary infection,and 6 cases (4.3%) of functional delayed gastric emptying. Four cases died during the perioperative period.The overall mortality rate were 2.9%.Conclusions;The main complications after PD were hemorrhage,pancreatic leakage,bile duct leakage and intraabdominal cavity infection.Meticulons operative technique, the selection of appropriate anastomoses technique, careful observation and timely aggressive management in the postoperative period are the key points to reduce postoperative morbidity and motality rate after PD.