Objective:To study the feasibility of laparoscopic resection of colorectal cancer. Methods:A retrospectively analysis of the clinical data of 110 patients with colorectal cancer treated by laparoscopic resection during last three years was made. Of them, 24 cases were converted to open operation.In 86 cases, laparoscopic resection of colorectal cancer was completed. Among them, 5 cases underwent right hemicolectomy, 2 cases left hemicolectomy,10 cases sigmoidectomy, 22 cases Dixon′s operation, 46 cases of Miles operation, and 1 case total colorectomy. Results:No patient died within 30 days postoperatively in this series. The average operation time was 225 (120360) min with average 135 (20400) mL blood loss.The average number of lymph nodes excised was 8.7 (130). The average number of positive lymph nodes was 2.2 (024). Six cases had intraoperative complications, including 1 case of ureteral injury and 5 cases of intraabdominal bleeding. These patients were immediately converted to open surgery. There were 6 cases with postoperative complications, among them, 2 cases of urinary leakage, 2 cases of massive bleeding and 2 cases of intestinal obstruction. All of them recovered after reoperation.The time of bowel funtion recovering was 1272h after operation. The hospital stay after operation was 8.6 (715)days. The median followup was 14.3 months (range 133) for 100 (90.9%) patients. There was no portsite tumor metastasis and no tumor recurrence at the small abdominal incision. Six to fifteen months after opteration, 3 cases had diffase peritoneal metastases.1 case of Miles resection had perineal metastasis 3 months after surgery. Conclusions:Laparoscopic resection of colorectal cancer is technically feasible,and have advantages, such as less surgical trauma, less bleeding, less gastrointestinal interference and quicker recovery.Laparoscopic radical operation for colorectal cancer can meet the requirements of safety and radical operation.