Abstract:Objective:To evaluate the therapeutic effect,prognostic factors and the methods to improve long term survival of liver resection for hepatic metastases of colorectal cancer.Methods: 52 patients operated on for hepatic metastases from colorectal cancer were followed up,and the clinical and pathologic data of 11 cases,who survived more than 5 years,were compared with 41 survivors of less than 5 years after hepatic resection.Results: The 1-,3-and 5-year survival rate was 75.0%,30.8%,and 21.2%,respectively.The important factors affecting prognosis were pathologic type of the primary cancer,number of hepatic metastasis,selection of the methods and timing of surgery,and postoperative treatment(P<0.05).Conclusions:The cruxes to improve long-term therapeutic results are radical resection and intensive postoperative combined therapy.