Abstract:Objective:To study the surgical treatment of duodenal invasion by cancer of hepatic flexure of colon. Methods:Clinical data of 15 cases of duodenal invasion by cancer of hepatic flexure of colon were analyzed retrospectively.Results:Invasion of the second or third portion of the duodenum by cancer of the hepatic flexure of colon occurred in 15 cases.The duodenum was adhered to the cancer in 6 cases,seromuscular invasion by the tumor in 5 cases,and duodenocolic fistula in 4 cases. All of the cases received surgical treatment. 8 cases were mucoid adenocarcinomas, 4 were poorly differentiated adenocarcinomas, two were moderately differentiated adenocarcinomas, and one was signet-ring cell carcinoma. One patient died after operation, and the five-year survival rate was 46.7%（7/15）. Conclusions:Duodenum is the first organ easily to be invaded by cancer of hepatic flexare of colon. Radical and en bloc resection of the colonic cancer and involved organs is the best therapeutic method. The key to recovery is correct treatment of the surgical defect of the duodenum.