Abstract:Objective:To study the expressions of XIAP and survivin in breast carcinoma tissues and their value in predicting the recurrence of breast carcinoma. Methods:The expression of XIAP and survivin in 65 benign and 65 malignant breast paraffin-embedded specimens was detected by using immunohistochemical assay and the results were compared. Results:The positive rate of XIAP and survivin in recurrent breast carcinoma (recurrent group) was 82.2％ and 85.7％ respectively, and in non-recurrent breast carcinoma tissue（non-recurrent group) was 54.5％ and 45.5％ respectively,and in both groups were increased significantly as compared with that of benign breast tissues（20.0％,and 13.3％ respectively）. The positive expression of XIAP and survivin was increased significantly in recurrent group as compared with non-recurrent group (P＜0.01）. In recurrent group, XIAP expression had a positive correlation with histologic grade（r=0.472,P＜0.05）,but negative correlation to estrogen and progesterone receptors（r=-0.486,P＜0.05）;survivin expression also had a positive correlation with histologic grade（r=0.532,P＜0.05）;XIAP and surviving expression had positive correlation（r=0.447,P＜0.05）. Conclusions:XIAP and survivin oncogene may play an important role in the development of breast cancer, and suggests that their combined detection is valuable for better prediction of the prognosis of breast cancer.