Abstract:Objective:To investigate the effects of hyperoxic-hyperosmotic sodium chloride solution(HHSCS) on arterial blood gas and blood lactate in rabbits with hemorrhagic shock, and evaluate the HHSCS effects on hemorrhagic shock resuscitation. Methods:Hemorrhagic shock models were induced in 30 male rabbits. The median arterial pressure(MAP) was declined to 40mmHg within 10 minutes, then maintained for 60 minutes. The animals were then randomly divided into 3 groups:normal saline hyperoxic solution (NSO)group, hyperosmotic sodium chloride solution (HS)group and HHSCS group. Sixty minutes later, NSO，HS or HHSCS 6ml/kg was infused intravenously in 5 minutes. Heart rate(HR) 、respiratory rate(RR)、 MAP and urine drops(UD) before shock and after fluid infusion were recorded; blood lactate(BL) and blood gas were measured before shock，60min after shock，and 30min，60min，120min postinfusion. Finally, the rabbits were killed by bleeding, the lungs were observed in autopsy, and the lung coefficient was measured. Results:HS and HHSCS more effectively raised MAP,enhanced heart function,and increased UD than NSO. HHSCS group significantly reduced BL. At 60,120min after infusion, SaO2 in HHSCS group was significantly higher than that in HS group and NSO group(P<0.05),and PaO2 was significantly higher than HS group and NSO group at 30 min after infusion(P<0.05). The lung coefficient in HS group、HHSCS group was less than that in NSO group(P<0.01). Conclusions:HHSCS can more efficiently decrease BL and increase blood SaO2 and PaO2 than NSO and HS did, and is more effective for hemorrhagic shock resuscitation.