Abstract:Objective:To evaluate recombinant adenovirus microspheres encapsulated with antisense MRP (as-mrp) on reversion of hepatocellular carcinoma.
Methods :The rats were divided randomly into 5 groups:control group; hepatic arterial injection of normal saline group, microspheres carrying no viruses group, rAdV carrying as-mrp group, and microspheres with encapsulation of as-mrp rAdV (MER) group. The theraputic effect were observed.
Results:The tumor growth inhibition and the mean life time in MER group were superior to than of other 4 groups (P<0.05). The tumor tissue were observed to have fluorescence intensity, but was negative in other tissues.
Conclusions:Recombinant adenovirus microspheres can effectively inhibit HCC.