复合血管与倒置大隐静脉旁路移植治疗严重慢性下肢缺血的对比研究
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罗涛

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The effect of composite sequential bypass and reversed saphenous vein bypass on limb salvage for critical limb ischemia: a comparative study
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    摘要:

    目的:比较复合血管序贯式下肢动脉旁路术和倒置自体大隐静脉旁路术治疗严重慢性下肢缺血的效果。
    方法:回顾性分析采用复合式血管(25例)及倒置自体大隐静脉(16例)旁路移植术治疗的41例严重慢性下肢缺血患者的临床资料。复合血管用聚四氟乙烯(PTFE)人工血管及自体静脉组合而成。人工血管近心端与股总动脉吻合, 远端与孤立腘动脉吻合;自体静脉从PTFE血管远端发出并与小腿的胫或腓动脉吻合。倒置自体大隐静脉旁路术采用同侧大隐静脉作为血管桥。比较两者血管桥的累积通畅率和保肢率。
    结果:平均随访18.7个月。男29例, 女12例。平均年龄(67±10.4)岁。FontaineⅢ级23例, FontaineⅣ级18例。复合血管组中自体静脉远端吻合口止于胫前动脉5例, 胫后动脉14例, 腓动脉6例;倒置大隐静脉移植组中10例吻合口止于胫后动脉, 3例腓动脉, 3例胫前动脉。复合血管组踝肱指数术前为0.24±0.14, 术后为0.68±0.22(P=0.000)。倒置大隐静脉组平均踝肱指数术前为0.24±0.14, 术后为0.68±0.22(P=0.000)。复合血管术后1, 2, 3年首次通畅率分别为78%, 72%, 61%;二期通畅率分别为83%, 76%, 66%; 1, 2, 3年救肢率分别为83%, 83%, 73%。倒置自体大隐静脉组1, 2, 3年首次通畅率分别为86%, 73%, 73%;二期通畅率分别为86%, 73%, 73%;1, 2, 3年累计救肢率分别为93%, 79%, 79%。两组比较差异无显著性(P>0.05)。
    结论:当静脉存在缺陷不能行倒置自体大隐静脉旁路术时, 选择组合式血管可以获得较高通畅率, 并有较好的救肢效果。

    Abstract:

    Objective:To compare the outcome of composite sequential bypass and reversed autologous saphenous vein bypass for severe chronic lower limb ischemia.
    :Methods :From 2003 to 2005, 41 patients presenting with critical limb ischemia were divided into 2 groups: In 25 cases composite sequential bypass was carried out,While in 16 cases reversed autologous saphenous vein bypass was done. The composite sequential bypass was done with PTFE anastomosed proximally to the common femoral artery and distally to the isolated popliteal artery, and autologous saphenous vein extended from the distal PTFE and anastomosed to tibial or peroneal artery. The results were analysed by life table methods to discover the difference of primary patency, secondary patency and limb salvage between the 2 groups.
    :Results:There were 18 patients with gangrene and 23 patients with rest pain.The mean age of patients was 67 years (range, 48-86 years). The cohort consisted of 29 male and 12 female patients.The mean follow-up was 18.7 months. In the composite graft group the outflow involved the peroneal artery in 6, the posterior tibial artery in 14, and the anterior tibial artery in 5.Primary graft patency at 1 y, 2 y and 3 y by lifetable analysis was 78%, 72% and 61%, respectively.Secondary graft patency of each year was 83%, 76% and 66%, respectively. Limb salvage rate was 83%, 73% and 73%, respectively. In the reversed saphenous vein group the outflow involved the peroneal artery in 3, the posterior tibial artery in 10, and the anterior tibial artery in 3. Primary graft patency at 1 y, 2 y and 3 y by lifetable analysis was 83%, 73% and 73%, respectively.Secondary graft patency of each year was 86%, 73% and 73%, respectively.Limb salvage rate was 93%, 79% and 79%, respectively.By the logrank test, there was not significent difference between the 2 groups.
    :Conclusions:Composite sequential reconstruction using an isolated popliteal segment as supporting point for the distal reconstruction is an acceptable option in patients presenting with serious limb ischemia without enough venous conduit for distal bypass.

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罗涛, 谷涌泉, 俞恒锡, 李学锋, 齐立行, 李建新, 张建, 汪忠镐.复合血管与倒置大隐静脉旁路移植治疗严重慢性下肢缺血的对比研究[J].中国普通外科杂志,2008,17(12):1-116.
DOI:10.7659/j. issn.1005-6947.2008.12.001

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  • 在线发布日期: 2008-12-25